Description
This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers. Table of Contents: 1. Introduction to Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma Michael J. Murphy 2. Diagnostic and Prognostic Biomarkers in Melanoma: Current State of Play Jochen Utikal, Jrgen C. Becker, and Selma Ugurel 3. Molecular Pathogenesis of Melanoma: Established and Novel Pathways Paolo Antonio Ascierto, Maria Libera Ascierto, Mariaelena Capone, Zendee Elaba, Michael J. Murphy, and Giuseppe Palmieri 4. Staging of Melanoma Zendee Elaba, Michael J. Murphy, Philip Kerr, and Jane M. Grant-Kels 5. Clinical and Histopathological Parameters in Melanoma Cheryl Bilinski, Avery LaChance, and Michael J. Murphy 6. Genetic/Epigenetic Biomarkers: Distinction of Melanoma from Other Melanocytic Neoplasms Minoru Takata 7. mRNA Biomarkers in Melanoma Giovanna Chiorino and Maria Scatolini 8. Epigenetic Biomarkers in Melanoma Suhu Liu, Suping Ren, Paul M. Howell Jr., and Adam I. Riker 9. microRNA Biomarkers in Melanoma Jim Kozubek, Faseeha Altaf and Soheil S. Dadras 10. MicroRNAs as Biomarkers and Therapeutic Targets in Melanoma Daniel W. Mueller, Anja K. Bosserhoff 11. Mitochondrial DNA Biomarkers in Melanoma Mark L. Steinberg 12. Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (A) Diagnosis Steven J. Ohsie, Basil A. Horst, Alister Cochran, and Scott W. Binder 13. Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (B) Prognostication Basil A. Horst, Steven J. Ohsie, Alister Cochran, and Scott W. Binder 14. Tissue-Based Protein Biomarkers in Melanoma: Mass Spectrometry-Based Strategies Michael J. Murphy, Karim Rezaul, and David K. Han 15. Serological Biomarkers in Melanoma Mel Ziman, Michael Millward, Robert Pearce, and Mark Lee 16. Molecular Markers of Lymph Node Disease in Melanoma Sandro Pasquali, Augustinus P.T. van der Ploeg, and Simone Mocellin 17. Melanoma Cell Propagation: Cancer Stem Cell, Clonal Evolution and Interconversion Models of Tumorigenicity Qiuzhen Liu, Marianna Sabatino, David F. Stroncek, Ping Jin, Francesco M. Marincola, and Ena Wang 18. Surgical Management of Melanoma: Concept of Field Cancerization and Molecular Evaluation of Tissue Margins Amanda Phelps and Michael J. Murphy 19. Chemotherapy for Melanoma Hedwig Stanisz, Thomas Vogt, and Knuth Rass 20. Molecular-Targeted Therapy for Melanoma Alessia E. Russo, Ylenia Bevelacqua, Andrea Marconi, Andrea Veronesi, and Massimo Libra 21. Anti-Angiogenesis Therapy for Melanoma Roberta Ferraldeschi and Paul Lorigan 22. Immunological Biomarkers and Immunotherapy for Melanoma Jochen T. Schaefer 23. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma: An Overview Ahmad A. Tarhini and John M. Kirkwood
